Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 10/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 10/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 10/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 10/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 8/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 8/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 8/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 8/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.43 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.43 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557963 | 0.88 | GRIN2D (0.40) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7505258 | 0.81 | GRIN2D (0.57) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL9043231 | 0.80 | POLB (0.48) | — | |
| SCHEMBL8557499 | 0.78 | PDE5A (0.46) | — | |
| SCHEMBL8556815 | 0.76 | GRIN2D (0.37) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8553450 | 0.73 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8557148 | 0.69 | GRIN2D (0.45) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8557394 | 0.68 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7506851 | 0.67 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL9037767 | 0.67 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691846-B1 | IMIDAZOLO-QUINOXALINONES FOR TREATING DISEASES OF THE CENTRAL NERVOUS SYSTEM | BASF AG (DE) | 2001-08-01 | — | — | EP | disclosed |