Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 6/20 | 1.00 |
| ▸ | ESR1 | P03372 | 2/20 | 0.79 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.74 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.74 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.74 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.74 |
| ▸ | TYR | P14679 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13287172 | 0.96 | SERPINE1 (0.92) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL28100061 | 0.94 | SERPINE1 (0.89) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL24871867 | 0.94 | SERPINE1 (0.89) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL27797541 | 0.94 | SERPINE1 (0.89) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL13286951 | 0.94 | SERPINE1 (0.89) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL2791373 | 0.91 | SERPINE1 (1.00) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL28384704 | 0.90 | SERPINE1 (0.82) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL8382124 | 0.89 | SERPINE1 (0.79) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL7157702 | 0.89 | SERPINE1 (0.79) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 | |
| Butyl Gallate SCHEMBL35913 | 0.89 | ESR1 (1.00) | SERPINE1ESR1AKR1C4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023281063-A1 | BROAD-SPECTRUM ANTIVIRAL DRUGS | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2023-01-12 | — | — | WO | disclosed |
| US-9527878-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-12-27 | — | — | US | disclosed |
| US-9527878-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160009748-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-14 | — | — | US | disclosed |
| US-20160009748-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-14 | — | — | US | disclosed |
| US-9120744-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-01 | — | — | US | disclosed |
| US-9120744-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-01 | — | — | US | disclosed |
| US-9096501-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096501-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140343321-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-20 | — | — | US | disclosed |
| CN-101366699-B | Novel lipid composition aerosol for the controlled release of pharmaceutically active ingredients | UNIV HONG KONG BAPTIST | 2014-04-16 | — | — | CN | disclosed |
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2010-06-03 | — | — | US | disclosed |
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2010-06-03 | — | — | US | disclosed |
| CN-101366699-A | Novel liposomal aerosol for the controlled release of pharmaceutically active ingredients | UNIV HONG KONG BAPTIST (HK) | 2009-02-18 | — | — | CN | disclosed |
| US-20090011055-A1 | Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-01-08 | — | — | US | disclosed |
| US-20090011055-A1 | Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-01-08 | — | — | US | disclosed |
| WO-2008131047-A2 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-30 | — | — | WO | disclosed |
| EP-0445819-B1 | Positive type photoresist composition | FUJI PHOTO FILM CO LTD (JP) | 2001-08-22 | — | — | EP | disclosed |
| EP-0445819-A2 | Positive type photoresist composition | FUJI PHOTO FILM CO., LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |
| EP-0148787-A2 | Positive type photosensitive resin composition | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1985-07-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | SERPINE1, PLAT, SERPINB1 | SERPINE1 1/4885ESR1 4241/4885AKR1C4 477/4885 |
| US-20160009748-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM | SERPINE1, PLAT, SERPINB1 | SERPINE1 1/4885ESR1 4241/4885AKR1C4 477/4885 |
| US-20140343321-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | SERPINE1, PLAT, SERPINB1 | SERPINE1 1/4885ESR1 4241/4885AKR1C4 477/4885 |
| US-20090011055-A1 | Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism | SERPINE1, PLAT, SERPINB1 | SERPINE1 1/4885ESR1 4241/4885AKR1C4 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.