Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7776209 | 0.83 | MEN1 (0.57) | GPR119ABCB1MAPTL3MBTL1HTR2A | |
| SCHEMBL7769768 | 0.82 | GPR119 (0.47) | GPR119ABCB1ALDH1A1MAPTNPC1 | |
| SCHEMBL7776181 | 0.81 | GPR119 (0.48) | GPR119ABCB1ALDH1A1MAPTNPC1 | |
| SCHEMBL7776155 | 0.80 | KMT2A (0.53) | ABCB1MAPTL3MBTL1HTR2AMEN1 | |
| SCHEMBL7776040 | 0.79 | CETP (0.55) | GPR119ALDH1A1MAPTCHRM2CHRM4 | |
| SCHEMBL8890641 | 0.79 | ABCB1 (0.50) | ABCB1ALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL21686038 | 0.75 | GPR119 (0.59) | GPR119ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL12408091 | 0.74 | ABCB1 (0.52) | ABCB1ALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL1498998 | 0.72 | ABCB1 (0.45) | GPR119ABCB1ALDH1A1MAPTCHRM2 | |
| SCHEMBL1223408 | 0.71 | ABCB1 (0.51) | ABCB1ALDH1A1MAPTNPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574906-B1 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO (JP) | 2001-08-22 | — | — | EP | disclosed |
| US-5380724-A | Inhibitors of lipid peroxidation | GYOGYSZERKUTATO INTEZET KFT (HU) | 1995-01-10 | — | — | US | disclosed |
| EP-0574906-A2 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-12-22 | — | — | EP | disclosed |