Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | PNP | P00491 | 6/20 | 0.48 |
| ▸ | HBB | P68871 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HPRT1 | P00492 | 9/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901757 | 0.88 | MEN1 (0.57) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL7773468 | 0.87 | PDE3A (0.55) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL10813642 | 0.82 | BLM (0.62) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL9414136 | 0.81 | HPRT1 (0.54) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL7778380 | 0.80 | HINT1 (0.40) | PDE3AMEN1KMT2APNPHBB | |
| SCHEMBL10812705 | 0.80 | BLM (0.67) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| Ganciclovir SCHEMBL1241831 | 0.79 | MEN1 (0.61) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL9192475 | 0.78 | PDE3A (0.60) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL9298573 | 0.78 | PDE3A (0.60) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL6839494 | 0.77 | PDE3A (0.59) | PDE3AMEN1KMT2ABLMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877746-B1 | PROCESS FOR PREPARING PURINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2001-09-19 | — | — | EP | disclosed |
| US-5700936-A | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate | SYNTEX (U.S.A.) INC. (US) | 1997-12-23 | — | — | US | disclosed |
| EP-0375329-B1 | Antiviral pyrimidine and purine compounds, process for their preparation and pharmaceutical compositions containing them | WELLCOME FOUND (GB) | 1995-05-31 | — | — | EP | disclosed |
| US-5318974-A | Amino acid esters of pyrimidine; used in the treatment of herpes virus infections | BURROUGHS WELLCOME CO. (US) | 1994-06-07 | — | — | US | disclosed |