Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7775664 | 0.89 | PAOX (0.37) | ALDH1A1KMT2ATSHRMEN1FAAH | |
| SCHEMBL7778631 | 0.84 | TSHR (0.35) | ALDH1A1CYP2C9HPGDALOX15CYP2C19 | |
| SCHEMBL24040342 | 0.84 | CA2 (0.34) | ALDH1A1CYP2C9HPGDALOX15CYP2C19 | |
| SCHEMBL13018276 | 0.82 | GLP1R (0.36) | CYP2C19TSHR | |
| SCHEMBL12730446 | 0.79 | TSHR (0.42) | ALDH1A1CYP2C9HPGDCYP2C19KMT2A | |
| SCHEMBL12589997 | 0.79 | TSHR (0.42) | ALDH1A1CYP2C9HPGDCYP2C19KMT2A | |
| SCHEMBL7771284 | 0.78 | HSD17B10 (0.34) | ALDH1A1HSD17B10KMT2ATSHRMEN1 | |
| SCHEMBL15765871 | 0.78 | MEN1 (0.37) | KMT2ATSHRMEN1 | |
| SCHEMBL14864751 | 0.78 | NAMPT (0.42) | ALDH1A1HPGDHSD17B10KMT2ATSHR | |
| SCHEMBL14378850 | 0.78 | POLB (0.38) | ALDH1A1CYP2C9HPGDALOX15CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |