Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.40 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036035 | 0.93 | MEN1 (0.48) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL7802471 | 0.91 | NPC1 (0.41) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL7802500 | 0.87 | LRRK2 (0.46) | MAP2K1MEN1KMT2ATDP1PTGS2 | |
| SCHEMBL6035385 | 0.87 | MAP2K1 (0.53) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL5389864 | 0.86 | MAP2K1 (0.56) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL7941506 | 0.86 | MEN1 (0.38) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL5378884 | 0.86 | PTGS2 (0.52) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL7800490 | 0.81 | MAP2K1 (0.50) | MAP2K1MAP2K2KMT2AGPR52MT-CO2 | |
| SCHEMBL6035704 | 0.81 | PTGS2 (0.48) | MAP2K1MEN1KMT2ATDP1PTGS2 | |
| SCHEMBL6036043 | 0.81 | MAP2K1 (0.55) | MAP2K1MAP2K2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |