Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802471 | 0.95 | NPC1 (0.41) | MEN1KMT2ATDP1NPC1RAB9A | |
| SCHEMBL7938698 | 0.87 | KMT2A (0.35) | MEN1KMT2APTGS2AKR1C3CNR1 | |
| SCHEMBL7780221 | 0.86 | MAP2K1 (0.46) | MEN1KMT2ATDP1NPC1RAB9A | |
| SCHEMBL7787480 | 0.86 | MAP2K1 (0.44) | MEN1KMT2ATDP1HPGDHSD17B10 | |
| SCHEMBL7802500 | 0.84 | LRRK2 (0.46) | MEN1KMT2ATDP1NPC1RAB9A | |
| SCHEMBL7784773 | 0.83 | MAPT (0.36) | MEN1KMT2ATDP1PTGS2AKR1C3 | |
| SCHEMBL7802481 | 0.81 | MEN1 (0.35) | MEN1KMT2ATDP1NPC1RAB9A | |
| SCHEMBL7784763 | 0.80 | MT-CO2 (0.42) | NPC1RAB9ACNR1FAAHCNR2 | |
| SCHEMBL6036035 | 0.80 | MEN1 (0.48) | MEN1KMT2ATDP1NPC1RAB9A | |
| SCHEMBL7800490 | 0.80 | MAP2K1 (0.50) | KMT2AHPGDHSD17B10MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140291-A1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER-LAMBERT COMPANY LLC (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037141-A9 | COMBINATION CHEMOTHERAPY | WARNER LAMBERT CO (US) | 2000-12-07 | — | — | WO | disclosed |
| WO-2000037141-A1 | COMBINATION CHEMOTHERAPY | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |