Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036035 | 0.94 | MEN1 (0.48) | LRRK2MEN1KMT2ATDP1PTGS2 | |
| SCHEMBL6035704 | 0.94 | PTGS2 (0.48) | LRRK2MEN1KMT2ATDP1PTGS2 | |
| SCHEMBL7802471 | 0.89 | NPC1 (0.41) | LRRK2MEN1KMT2ATDP1PTGS2 | |
| SCHEMBL5395241 | 0.88 | MAP2K1 (0.53) | LRRK2MEN1KMT2ATDP1PTGS2 | |
| SCHEMBL5389864 | 0.88 | MAP2K1 (0.56) | MEN1KMT2ATDP1PTGS2MAP2K1 | |
| SCHEMBL7780221 | 0.87 | MAP2K1 (0.46) | MEN1KMT2ATDP1PTGS2MAP2K1 | |
| SCHEMBL5378884 | 0.87 | PTGS2 (0.52) | MEN1KMT2ATDP1PTGS2MAP2K1 | |
| SCHEMBL7941506 | 0.84 | MEN1 (0.38) | LRRK2MEN1KMT2ATDP1PTGS2 | |
| SCHEMBL6035984 | 0.79 | NPC1 (0.53) | MEN1KMT2APTGS2MAP2K1NPC1 | |
| SCHEMBL7787193 | 0.79 | PTGS2 (0.42) | LRRK2MEN1KMT2APTGS2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143957-A3 | TREATMENT OF ARTHRITIS WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-1143957-A2 | TREATMENT OF ARTHRITIS WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-1140046-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035435-A9 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER LAMBERT CO (US) | 2001-03-22 | — | — | WO | disclosed |
| WO-2000035435-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |
| WO-2000035436-A2 | TREATMENT OF ARTHRITIS WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |