Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.48 |
| ▸ | BRAF | P15056 | 8/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.40 |
| ▸ | LIPE | Q05469 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781113 | 0.93 | KDR (0.50) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL7776073 | 0.89 | KDR (0.48) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL7776080 | 0.87 | KDR (0.52) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL7775742 | 0.86 | KDR (0.48) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL7978765 | 0.86 | KDR (0.56) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL7776101 | 0.84 | KDR (0.42) | KDRBRAFRAF1MAPK3HTR2A | |
| SCHEMBL7781138 | 0.84 | KDR (0.42) | KDRBRAFRAF1MAPK3HTR2A | |
| SCHEMBL8683809 | 0.82 | KDR (0.48) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL7781098 | 0.81 | KDR (0.40) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL7978762 | 0.81 | EGFR (0.47) | KDRBRAFMAPK14TNNI3KEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972770-B1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | BASF AG (DE) | 2001-09-19 | — | — | EP | claimed |
| US-6281219-B1 | 4,6-BIS-ARYL-PYRIMIDINES WHEREIN THE AROMATIC GROUPS ARE ATTACHED VIA TWO LINKING GROUPS WHICH ARE DIFFERENT FROM ONE ANOTHER. | AMERICAN CYANAMID CO. | 2001-08-28 | — | — | US | claimed |
| EP-0972770-A1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | American Cyanamid Company (US) | 2000-01-19 | — | — | EP | claimed |
| EP-0972770-B1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | BASF AG (DE) | 2001-09-19 | — | — | EP | disclosed |
| US-6281219-B1 | 4,6-BIS-ARYL-PYRIMIDINES WHEREIN THE AROMATIC GROUPS ARE ATTACHED VIA TWO LINKING GROUPS WHICH ARE DIFFERENT FROM ONE ANOTHER. | AMERICAN CYANAMID CO. | 2001-08-28 | — | — | US | disclosed |
| EP-0972770-A1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | American Cyanamid Company (US) | 2000-01-19 | — | — | EP | disclosed |