Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.56 |
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.56 |
| ▸ | BRAF | P15056 | 8/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7776080 | 0.92 | KDR (0.52) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7781113 | 0.89 | KDR (0.50) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7776073 | 0.87 | KDR (0.48) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7780252 | 0.86 | KDR (0.48) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7978762 | 0.83 | EGFR (0.47) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7775742 | 0.82 | KDR (0.48) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7780255 | 0.80 | KDR (0.46) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7783042 | 0.79 | KDR (0.45) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7783043 | 0.78 | KDR (0.44) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL7782549 | 0.77 | RXRA (0.54) | KDRMAPK14TNNI3KBRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281219-B1 | 4,6-BIS-ARYL-PYRIMIDINES WHEREIN THE AROMATIC GROUPS ARE ATTACHED VIA TWO LINKING GROUPS WHICH ARE DIFFERENT FROM ONE ANOTHER. | AMERICAN CYANAMID CO. | 2001-08-28 | — | — | US | disclosed |