Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 7/20 | 0.40 |
| ▸ | RAF1 | P04049 | 5/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781138 | 1.00 | KDR (0.42) | KDRPLA2G7RAF1MAPK3BRAF | |
| SCHEMBL7781098 | 0.95 | KDR (0.40) | KDRPLA2G7RAF1MAPK3BRAF | |
| SCHEMBL7048715 | 0.94 | KDR (0.40) | KDRPLA2G7BRAFHTR2ASLC6A4 | |
| SCHEMBL7780252 | 0.84 | KDR (0.48) | KDRRAF1MAPK3BRAFHTR2A | |
| SCHEMBL679527 | 0.84 | KDR (0.49) | KDRPLA2G7RAF1MAPK3BRAF | |
| SCHEMBL7780255 | 0.83 | KDR (0.46) | KDRBRAF | |
| SCHEMBL7776073 | 0.83 | KDR (0.48) | KDRRAF1BRAF | |
| SCHEMBL7782975 | 0.81 | RAF1 (0.39) | KDRPLA2G7RAF1MAPK3BRAF | |
| SCHEMBL7783034 | 0.81 | RAF1 (0.42) | KDRPLA2G7RAF1MAPK3BRAF | |
| SCHEMBL7780165 | 0.79 | KMO (0.52) | KDRBRAFHTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972770-B1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | BASF AG (DE) | 2001-09-19 | — | — | EP | claimed |
| US-6281219-B1 | 4,6-BIS-ARYL-PYRIMIDINES WHEREIN THE AROMATIC GROUPS ARE ATTACHED VIA TWO LINKING GROUPS WHICH ARE DIFFERENT FROM ONE ANOTHER. | AMERICAN CYANAMID CO. | 2001-08-28 | — | — | US | claimed |
| EP-0972770-A1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | American Cyanamid Company (US) | 2000-01-19 | — | — | EP | claimed |
| EP-0972770-B1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | BASF AG (DE) | 2001-09-19 | — | — | EP | disclosed |
| US-6281219-B1 | 4,6-BIS-ARYL-PYRIMIDINES WHEREIN THE AROMATIC GROUPS ARE ATTACHED VIA TWO LINKING GROUPS WHICH ARE DIFFERENT FROM ONE ANOTHER. | AMERICAN CYANAMID CO. | 2001-08-28 | — | — | US | disclosed |
| EP-0972770-A1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | American Cyanamid Company (US) | 2000-01-19 | — | — | EP | disclosed |