Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 7/20 | 0.44 |
| ▸ | BRAF | P15056 | 6/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.44 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7776080 | 0.84 | KDR (0.52) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7978765 | 0.83 | KDR (0.56) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7776073 | 0.82 | KDR (0.48) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7780252 | 0.81 | KDR (0.48) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7781113 | 0.79 | KDR (0.50) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7780255 | 0.78 | KDR (0.46) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7775742 | 0.75 | KDR (0.48) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7782549 | 0.74 | RXRA (0.54) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7783042 | 0.74 | KDR (0.45) | EGFRCSF1RKDRBRAFMAPK14 | |
| SCHEMBL7783043 | 0.71 | KDR (0.44) | EGFRCSF1RKDRBRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281219-B1 | 4,6-BIS-ARYL-PYRIMIDINES WHEREIN THE AROMATIC GROUPS ARE ATTACHED VIA TWO LINKING GROUPS WHICH ARE DIFFERENT FROM ONE ANOTHER. | AMERICAN CYANAMID CO. | 2001-08-28 | — | — | US | disclosed |