Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787857 | 1.00 | S1PR3 (0.40) | S1PR3PGRARTEAD4RAPGEF4 | |
| SCHEMBL7785139 | 0.87 | S1PR3 (0.40) | S1PR3PGRARTEAD4RAPGEF4 | |
| Hydrochloric Acid SCHEMBL7780307 | 0.87 | S1PR3 (0.39) | S1PR3PGRARTEAD4RAPGEF4 | |
| SCHEMBL7785672 | 0.87 | S1PR3 (0.39) | S1PR3PGRARTEAD4RAPGEF4 | |
| SCHEMBL7780371 | 0.85 | S1PR3 (0.38) | S1PR3PGRARRAPGEF4MAPKAPK2 | |
| SCHEMBL7804131 | 0.84 | CXCR2 (0.37) | S1PR3PGRARTEAD4CXCR2 | |
| SCHEMBL7805351 | 0.84 | CXCR2 (0.37) | S1PR3PGRARTEAD4CXCR2 | |
| SCHEMBL7780322 | 0.82 | CXCR2 (0.38) | S1PR3PGRARTEAD4CXCR2 | |
| SCHEMBL7785252 | 0.81 | MAPKAPK2 (0.40) | TEAD4CXCR2MAPKAPK2MAPK14 | |
| SCHEMBL7787727 | 0.81 | KMT2A (0.42) | PGRARTEAD4CXCR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | claimed |
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |