Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.56 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7789426 | 0.91 | ALDH1A1 (0.74) | ALDH1A1GAALMNASLC6A9SLC6A5 | |
| SCHEMBL7785221 | 0.90 | ALDH1A1 (0.64) | ALDH1A1GAALMNACYP3A4HTT | |
| SCHEMBL7785664 | 0.84 | ALDH1A1 (0.56) | ALDH1A1GAALMNASLC6A9SLC6A5 | |
| Hydrochloric Acid SCHEMBL7785333 | 0.82 | ALDH1A1 (0.74) | ALDH1A1GAALMNASLC6A9SLC6A5 | |
| SCHEMBL27530409 | 0.82 | MAPK1 (0.47) | ALDH1A1GAALMNAHTTMAPT | |
| SCHEMBL7785483 | 0.82 | MAPK1 (0.47) | ALDH1A1GAALMNAHTTMAPT | |
| SCHEMBL12350147 | 0.80 | MEN1 (0.54) | ALDH1A1LMNAHTTMAPTNPC1 | |
| SCHEMBL10155639 | 0.79 | MAPT (0.47) | ALDH1A1GAALMNAHTTMAPT | |
| SCHEMBL7780585 | 0.79 | KMT2A (0.54) | ALDH1A1GAALMNACYP3A4HTT | |
| SCHEMBL7780564 | 0.77 | MAPK1 (0.46) | ALDH1A1GAALMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |