Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 2/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785002 | 0.93 | MAPKAPK2 (0.36) | MAPKAPK2ALDH1A1 | |
| SCHEMBL7787799 | 0.91 | S1PR3 (0.35) | MAPKAPK2POLB | |
| SCHEMBL7780418 | 0.91 | MAPKAPK2 (0.36) | MAPKAPK2MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL7785671 | 0.91 | IDH1 (0.35) | MAPKAPK2POLBMAPT | |
| SCHEMBL7785293 | 0.89 | MAPKAPK2 (0.40) | MAPKAPK2MEN1KMT2APOLBGAA | |
| SCHEMBL7785121 | 0.89 | MAPKAPK2 (0.46) | MAPKAPK2MEN1KMT2APOLBGAA | |
| SCHEMBL7787598 | 0.88 | MAPKAPK2 (0.43) | MAPKAPK2MEN1KMT2APOLBGAA | |
| SCHEMBL7789161 | 0.86 | MEN1 (0.40) | MAPKAPK2MEN1KMT2APOLBKRAS | |
| SCHEMBL7789329 | 0.86 | MEN1 (0.40) | MAPKAPK2MEN1KMT2APOLBKRAS | |
| SCHEMBL7784990 | 0.86 | POLB (0.46) | MAPKAPK2MEN1KMT2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |