Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14153992 | 0.77 | RIPK1 (0.52) | RIPK1TSHRDRD2DRD4SMN1; SMN2 | |
| SCHEMBL16256504 | 0.76 | TSHR (0.43) | RIPK1TSHRDRD2DRD4 | |
| SCHEMBL5021618 | 0.73 | RIPK1 (0.48) | RIPK1DRD2DRD4SMN1; SMN2CNR1 | |
| SCHEMBL13450761 | 0.73 | EPHX1 (0.50) | RIPK1DRD2DRD4MAPK1SMN1; SMN2 | |
| SCHEMBL7780945 | 0.71 | CASP2 (0.48) | TSHRHPGDSMN1; SMN2 | |
| SCHEMBL9923566 | 0.71 | CNR1 (0.49) | RIPK1DRD2DRD4SMN1; SMN2CNR1 | |
| SCHEMBL4546721 | 0.71 | EPHX1 (0.53) | RIPK1DRD2DRD4MAPK1SMN1; SMN2 | |
| SCHEMBL14134865 | 0.71 | EPHX1 (0.53) | RIPK1DRD2DRD4MAPK1SMN1; SMN2 | |
| SCHEMBL14486557 | 0.70 | RIPK1 (0.46) | RIPK1TSHRDRD2DRD4MAPK1 | |
| SCHEMBL12334724 | 0.70 | RIPK1 (0.46) | RIPK1TSHRDRD2DRD4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0688314-B1 | PRODRUG DERIVATIVES OF ENZYME INHIBITORS WITH HYDROXYL GROUPS, METHODS OF PREPARING THEM AND THEIR USE | HOECHST AG (DE) | 2001-10-04 | — | — | EP | disclosed |