Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391322 | 0.79 | TSHR (0.50) | ALDH1A1MAPTLMNAL3MBTL1POLB | |
| SCHEMBL10003295 | 0.77 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAL3MBTL1POLB | |
| SCHEMBL31422770 | 0.75 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNAL3MBTL1POLB | |
| SCHEMBL5901793 | 0.74 | GAA (0.73) | ALDH1A1MAPTLMNAL3MBTL1POLB | |
| SCHEMBL5902530 | 0.73 | GAA (0.66) | ALDH1A1MAPTLMNAL3MBTL1POLB | |
| SCHEMBL8885710 | 0.73 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNAL3MBTL1POLB | |
| SCHEMBL28296071 | 0.72 | CYP1A2 (0.45) | ALDH1A1MAPTLMNAL3MBTL1POLB | |
| SCHEMBL16740459 | 0.72 | KMT2A (0.46) | ALDH1A1MAPTLMNAL3MBTL1POLB | |
| SCHEMBL8138373 | 0.71 | KDM4E (0.44) | ALDH1A1KDM4E | |
| SCHEMBL9671945 | 0.71 | ALDH1A1 (1.00) | ALDH1A1MAPTLMNAL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971919-B1 | PROCESS FOR PREPARATION OF 4H-4-OXO-QUINOLIZINE-3-CARBOXYLIC ACID DERIVATIVES | ABBOTT LAB (US) | 2001-10-31 | — | — | EP | disclosed |
| CN-1248256-A | Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid derivatives | ABBOTT LAB (US) | 2000-03-22 | — | — | CN | disclosed |
| EP-0971919-A1 | PROCESS FOR PREPARATION OF 4H-4-OXO-QUINOLIZINE-3-CARBOXYLIC ACID DERIVATIVES | Abbott Laboratories (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998038191-A1 | PROCESS FOR PREPARATION OF 4H-4-OXO-QUINOLIZINE-3-CARBOXYLIC ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-09-03 | — | — | WO | disclosed |
| US-5693813-A | Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid | ABBOTT LABORATORIES (US) | 1997-12-02 | — | — | US | disclosed |