Fantofarone

Fantofarone

SCHEMBL77818

COc1ccc(CCN(C)CCCOc2ccc(S(=O)(=O)c3c(C(C)C)cn4ccccc34)cc2)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.59
KDM4E B2RXH2 3/20 0.59
TP53 P04637 1/20 0.59
MAPT P10636 1/20 0.59
TSHR P16473 1/20 0.59
CYP2C19 P33261 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
SMPD1 P17405 6/20 0.45
PDE4D Q08499 2/20 0.43
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 2/20 0.41
ABCB1 P08183 2/20 0.41
BLM P54132 2/20 0.40
PMP22 Q01453 1/20 0.40
CYP2C9 P11712 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fantofarone SCHEMBL29802340 1.00 CYP3A4 (0.59) CYP3A4KDM4ETP53MAPTTSHR
Fantofarone SCHEMBL9599714 0.99 CYP3A4 (0.59) CYP3A4KDM4ETP53MAPTTSHR
SCHEMBL9598076 0.98 CYP3A4 (0.57) CYP3A4KDM4ETP53MAPTTSHR
SCHEMBL9156142 0.93 KDM4E (0.51) CYP3A4KDM4ETP53MAPTTSHR
SCHEMBL9157509 0.92 CYP3A4 (0.50) CYP3A4KDM4ETP53MAPTTSHR
Hydrochloric Acid SCHEMBL9655914 0.92 CYP3A4 (0.49) CYP3A4KDM4ETP53MAPTTSHR
SCHEMBL9598112 0.90 KDM4E (0.56) CYP3A4KDM4ETP53MAPTTSHR
SCHEMBL9656156 0.90 KDM4E (0.46) CYP3A4KDM4ETP53MAPTTSHR
SCHEMBL9215666 0.89 KDM4E (0.48) CYP3A4KDM4ETP53MAPTTSHR
SCHEMBL9155096 0.88 CYP3A4 (0.57) CYP3A4KDM4ETP53MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1344 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3498297-B1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AUTISM STALICLA S A (CH) 2023-06-21 EP claimed
US-20210154177-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AUTISM Stalicla S.A. (CH) 2021-05-27 US claimed
US-20210145803-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AUTISM Stalicla S.A. (CH) 2021-05-20 US claimed
EP-3498297-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AUTISM Stalicla S.A. (CH) 2019-06-19 EP claimed
CN-109821019-A Pharmaceutical composition for treating autism 斯塔利克拉股份有限公司 2019-05-31 CN claimed
US-20190134011-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AUTISM Stalicla S.A. (CH) 2019-05-09 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20140142124-A1 Compositions for Topical Application Having Androgenic Actions AVENTIS PHARMA SA (DE) 2014-05-22 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
WO-1999067231-A1 NITRATE SALTS OF ANTIHYPERTENSIVE MEDICINES NICOX S.A. (FR) 1999-12-29 WO claimed
CN-1210460-A Preparations stimulating nail growth HOECHST AG (DE) 1999-03-10 CN claimed
EP-0858325-A1 STABLE FREEZE-DRIED PHARMACEUTICAL FORMULATION SANOFI (FR) 1998-08-19 EP claimed
WO-1997017064-A1 STABLE FREEZE-DRIED PHARMACEUTICAL FORMULATION SANOFI (FR) 1997-05-15 WO claimed
WO-1996010406-A1 PHARMACEUTICAL COMPOSITION OF FANTOFARONE FOR ORAL ADMINISTRATION SANOFI (FR) 1996-04-11 WO claimed
EP-0639986-A1 TOPICAL OPHTHALMIC COMPOSITIONS COMPRISING A COMBINATION OF CALCIUM ANTAGONISTS WITH KNOWN ANTIGLAUCOMA AGENTS ALCON LABORATORIES, INC. (US) 1995-03-01 EP claimed
WO-1993023082-A1 TOPICAL OPHTHALMIC COMPOSITIONS COMPRISING A COMBINATION OF CALCIUM ANTAGONISTS WITH KNOWN ANTIGLAUCOMA AGENTS ALCON LABORATORIES, INC. (US) 1993-11-25 WO claimed
US-5017579-A Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure SANOFI (FR) 1991-05-21 US claimed
EP-0235111-B1 INDOLIZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM SANOFI S.A. (FR) 1991-04-10 EP claimed
US-4957925-A HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS, TREATMENT OF ANGINA SANOFI (FR) 1990-09-18 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140142124-A1 Compositions for Topical Application Having Androgenic Actions NR5A1, CYP17A1, CYP19A1 CYP3A4 2887/4885KDM4E 3855/4885TP53 2342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.