SCHEMBL7782406

SCHEMBL7782406

N#Cc1c(F)cc([N+](=O)[O-])cc1F

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 3/20 0.55
TRPV4 Q9HBA0 1/20 0.48
XDH P47989 1/20 0.43
CYP19A1 P11511 1/20 0.43
ALDH1A1 P00352 5/20 0.42
HIF1A Q16665 2/20 0.42
TSHR P16473 2/20 0.40
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
TLR9 Q9NR96 1/20 0.39
KDM4E B2RXH2 1/20 0.38
TTR P02766 1/20 0.38
CYP1A2 P05177 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL505035 0.79 VCAM1 (0.55) VCAM1XDHCYP19A1ALDH1A1HIF1A
SCHEMBL1438764 0.78 ALDH1A1 (0.44) VCAM1XDHALDH1A1MEN1KMT2A
SCHEMBL14744347 0.76 VCAM1 (0.52) VCAM1XDHCYP19A1ALDH1A1HIF1A
SCHEMBL5035508 0.75 ALDH1A1 (0.59) VCAM1XDHCYP19A1ALDH1A1TSHR
SCHEMBL23088374 0.75 VCAM1 (0.55) VCAM1XDHCYP19A1ALDH1A1TSHR
SCHEMBL239666 0.75 CYP19A1 (0.52) VCAM1CYP19A1ALDH1A1HIF1ATSHR
SCHEMBL14318559 0.75 VCAM1 (0.39) VCAM1XDHALDH1A1HIF1AMEN1
SCHEMBL14325891 0.75 VCAM1 (0.39) VCAM1XDHALDH1A1HIF1AMEN1
SCHEMBL19452120 0.75 VCAM1 (0.46) VCAM1XDHCYP19A1ALDH1A1HIF1A
SCHEMBL361867 0.75 VCAM1 (0.59) VCAM1TRPV4XDHALDH1A1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0637623-B1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK & CHEMICALS (JP) 2001-10-04 EP disclosed
US-5536443-A DUTERIUM CONTAINING COMPOUNDS FOOR ELECTROOPTICAL APPARATUS DAINIPPON INK & CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5474707-A Electrooptic display DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-12-12 US disclosed
EP-0637623-A1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-02-08 EP disclosed