Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28501524 | 0.87 | — | — | |
| Acetic Acid SCHEMBL5316671 | 0.85 | — | — | |
| Maleic Acid SCHEMBL16228194 | 0.80 | TSHR (0.47) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL16228196 | 0.80 | TSHR (0.47) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL2597 | 0.79 | — | — | |
| Maleic Acid SCHEMBL1639455 | 0.78 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL1639460 | 0.78 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Acrylamide SCHEMBL28837510 | 0.76 | TSHR (0.52) | TSHRALDH1A1SMN1; SMN2MAPTKMT2A | |
| Water SCHEMBL6400627 | 0.76 | — | — | |
| SCHEMBL31507590 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736582-B1 | Ink, ink-jet recording process and apparatus using the same | CANON KK (JP) | 2001-10-10 | — | — | EP | disclosed |
| US-6174354-B1 | AMPHOTERIC POLYMER HAVING BOTH ANIONIC AND CATIONIC GROUPS. | CANON KABUSHIKI KAISHA (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0736582-A2 | Ink, ink-jet recording process and apparatus using the same | CANON KABUSHIKI KAISHA (JP) | 1996-10-09 | — | — | EP | disclosed |