Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL1639455 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL16228194 | 0.97 | TSHR (0.47) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL16228196 | 0.97 | TSHR (0.47) | TSHRTP53EGLN1EGLN3MAPT | |
| Acrylic Acid SCHEMBL2790689 | 0.87 | LMNA (0.53) | TSHRMAPTSMN1; SMN2LMNAKMT2A | |
| Acrylic Acid SCHEMBL27988712 | 0.85 | LMNA (0.50) | TSHRMAPTSMN1; SMN2LMNAKMT2A | |
| Acrylic Acid SCHEMBL7071287 | 0.84 | LMNA (0.56) | TSHRMAPTSMN1; SMN2LMNAKMT2A | |
| Crotonic Acid SCHEMBL16860062 | 0.84 | TSHR (0.34) | TSHRTP53EGLN1EGLN3MAPT | |
| Acetic Acid SCHEMBL28514952 | 0.82 | SMN1; SMN2 (0.39) | TSHRMAPTSMN1; SMN2LMNAKMT2A | |
| Acrylic Acid SCHEMBL546829 | 0.79 | ALDH1A1 (0.48) | TSHRMAPTSMN1; SMN2LMNAKMT2A | |
| Acetic Acid SCHEMBL28451525 | 0.79 | SMN1; SMN2 (0.41) | TSHRMAPTSMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8597550-B2 | Method for producing water-resistant polarizing film | NITTO DENKO CORPORATION (JP) | 2013-12-03 | — | — | US | claimed |
| US-20110097483-A1 | METHOD FOR PRODUCING WATER-RESISTANT POLARIZING FILM | NITTO DENKO CORPORATION (JP) | 2011-04-28 | — | — | US | claimed |
| CN-103635554-A | Multilayer adhesive article and adhesive sheet | NITTO DENKO CORP | 2014-03-12 | — | — | CN | disclosed |
| US-8597550-B2 | Method for producing water-resistant polarizing film | NITTO DENKO CORPORATION (JP) | 2013-12-03 | — | — | US | disclosed |
| US-20110207160-A1 | METHOD FOR MEASURING LOW DENSITY LIPOPROTEIN CHOLESTEROL | FUJIFILM CORPORATION (JP) | 2011-08-25 | — | — | US | disclosed |
| US-20110097483-A1 | METHOD FOR PRODUCING WATER-RESISTANT POLARIZING FILM | NITTO DENKO CORPORATION (JP) | 2011-04-28 | — | — | US | disclosed |