SCHEMBL7783288

SCHEMBL7783288

CC(=O)Nc1ccccc1C(=O)Nc1ccc(N)cc1.Nc1ccc(NC(=O)c2ccc(F)cc2F)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.62
SMN1; SMN2 Q16637 2/20 0.56
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
CYP2C19 P33261 1/20 0.54
BDKRB1 P46663 1/20 0.53
LMNA P02545 2/20 0.52
HDAC3 O15379 1/20 0.52
HDAC2 Q92769 1/20 0.52
NCOR2 Q9Y618 1/20 0.52
SNCA P37840 1/20 0.51
AVPR2 P30518 1/20 0.51
GPR27 Q9NS67 1/20 0.51
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
RXFP1 Q9HBX9 1/20 0.50
KDM4E B2RXH2 1/20 0.49
KLK7 P49862 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
AURKA O14965 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6815864 0.86 MEN1 (0.64) HDAC1SMN1; SMN2NPC1RAB9ACYP2C19
SCHEMBL677811 0.85 SNCA (0.67) HDAC1SMN1; SMN2NPC1RAB9ALMNA
SCHEMBL28747395 0.77 LMNA (0.61) HDAC1SMN1; SMN2NPC1RAB9ALMNA
SCHEMBL15551311 0.77 HDAC1 (1.00) HDAC1SMN1; SMN2HDAC3HDAC2NCOR2
SCHEMBL679040 0.77 MEN1 (0.83) SMN1; SMN2NPC1RAB9ALMNAMEN1
SCHEMBL6544935 0.77 GPR27 (0.72) SMN1; SMN2NPC1RAB9ALMNASNCA
SCHEMBL15552355 0.75 HDAC1 (1.00) HDAC1SMN1; SMN2NPC1RAB9ALMNA
SCHEMBL11783963 0.75 MEN1 (0.68) SMN1; SMN2NPC1RAB9ACYP2C19LMNA
SCHEMBL27134473 0.75 KMT2A (0.77) SMN1; SMN2NPC1RAB9ACYP2C19LMNA
SCHEMBL25063018 0.74 KMT2A (0.66) SMN1; SMN2NPC1RAB9ACYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144397-A3 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP Wyeth (US) 2002-09-11 EP disclosed
EP-1144397-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-17 EP disclosed
WO-2000034258-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed