Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816455 | 0.86 | MAPT (0.59) | MAPTTDP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7573759 | 0.80 | ALDH1A1 (0.54) | MAPTALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL7845122 | 0.80 | ALDH1A1 (0.54) | MAPTALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL19174849 | 0.77 | MAPT (0.66) | MAPTTDP1ALDH1A1MAPK1HPGD | |
| SCHEMBL6811114 | 0.76 | ALDH1A1 (0.62) | MAPTALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL29139536 | 0.76 | ALDH1A1 (0.75) | MAPTTDP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL6815998 | 0.75 | ALDH1A1 (0.64) | MAPTALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL3546064 | 0.73 | LMNA (0.75) | MAPTTDP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL6815368 | 0.73 | ALDH1A1 (0.49) | MAPTTDP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL6816481 | 0.73 | ALDH1A1 (0.58) | MAPTTDP1ALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144397-A3 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | Wyeth (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1144397-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000034258-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |