Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786549 | 0.84 | TGFBR1 (1.00) | TGFBR1THRBPDE10AKDM4EHTT | |
| SCHEMBL9436258 | 0.82 | TGFBR1 (0.69) | TGFBR1TGFBR2PDE10AKDM4ETDP1 | |
| SCHEMBL17767754 | 0.82 | TGFBR1 (0.69) | TGFBR1THRBTGFBR2MAPK14 | |
| SCHEMBL17767437 | 0.81 | TGFBR1 (0.68) | TGFBR1THRBTGFBR2MAPK14 | |
| SCHEMBL17767722 | 0.79 | TGFBR1 (0.65) | TGFBR1THRBTGFBR2MEN1ALDH1A1 | |
| SCHEMBL373378 | 0.79 | TGFBR1 (1.00) | TGFBR1TGFBR2KDM4EHTTTDP1 | |
| SCHEMBL7343693 | 0.79 | TGFBR1 (0.65) | TGFBR1TGFBR2PDE10AKDM4ETDP1 | |
| SCHEMBL7378515 | 0.79 | TGFBR1 (0.65) | TGFBR1TGFBR2PDE10AKDM4ETDP1 | |
| SCHEMBL17767770 | 0.78 | TGFBR1 (0.63) | TGFBR1TGFBR2PDE10AKDM4E | |
| SCHEMBL7786197 | 0.77 | TGFBR1 (1.00) | TGFBR1THRBKDM4ETDP1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140129-A1 | HUMAN MAD PROTEINS AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035470-A1 | HUMAN MAD PROTEINS AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |