Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.69 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378515 | 0.93 | TGFBR1 (0.65) | TGFBR1TGFBR2PDE10AMAPK13MAPK12 | |
| SCHEMBL7343693 | 0.93 | TGFBR1 (0.65) | TGFBR1TGFBR2PDE10AMAPK13MAPK12 | |
| SCHEMBL9700043 | 0.89 | TGFBR1 (0.60) | TGFBR1TGFBR2PDE10AMAPK13MAPK12 | |
| SCHEMBL17767553 | 0.84 | TGFBR1 (0.59) | TGFBR1TGFBR2PDE10AMAPK13MAPK12 | |
| SCHEMBL11474337 | 0.84 | TGFBR1 (0.51) | TGFBR1TGFBR2PDE10ACSNK1DCSNK1E | |
| SCHEMBL11474839 | 0.84 | RAB9A (0.53) | TGFBR1TGFBR2PDE10ASMN1; SMN2KDM4E | |
| SCHEMBL11485609 | 0.83 | TGFBR1 (0.57) | TGFBR1TGFBR2PDE10ASMN1; SMN2KDM4E | |
| SCHEMBL13430532 | 0.83 | TGFBR1 (0.58) | TGFBR1TGFBR2PDE10AMAPK13MAPK12 | |
| Bromide SCHEMBL11473432 | 0.83 | TGFBR1 (0.50) | TGFBR1TGFBR2PDE10ACSNK1DCSNK1E | |
| SCHEMBL990288 | 0.83 | SMN1; SMN2 (0.66) | TGFBR1TGFBR2CSNK1DCSNK1ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231622-B1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORP (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | disclosed |