Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379205 | 0.90 | TGFBR1 (0.82) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11502937 | 0.86 | TGFBR1 (0.74) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7762981 | 0.82 | TGFBR1 (0.68) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL11369989 | 0.82 | TDP1 (0.87) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7378916 | 0.80 | MAPK14 (1.00) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL146947 | 0.80 | MAPK14 (1.00) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| Dimethylamine SCHEMBL9436026 | 0.79 | MAPK14 (0.71) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| Dimethylamine SCHEMBL9436089 | 0.79 | MAPK14 (0.71) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL170802 | 0.79 | KDM4E (1.00) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7784464 | 0.77 | TGFBR1 (1.00) | TGFBR1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140129-A1 | HUMAN MAD PROTEINS AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035470-A1 | HUMAN MAD PROTEINS AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
| EP-0231622-B1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORP (US) | 1994-08-24 | — | — | EP | disclosed |
| US-5317019-A | Antiinflammatory agents | SMITHKLINE BEECHAM CORP. (US) | 1994-05-31 | — | — | US | disclosed |
| US-5134150-A | Administering diaryl-substituted imidazothiazoles; antiarthritic agents | SMITHKLINE BEECHAM CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0403251-A2 | Monokine activity interference | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | disclosed |