Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 17/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 17/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 11/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 11/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794284 | 0.80 | KCNQ3 (0.45) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL7794281 | 0.70 | KCNQ3 (0.47) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL7784731 | 0.68 | FDFT1 (0.50) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL5618326 | 0.67 | ALDH1A1 (0.57) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL7794868 | 0.67 | FDFT1 (0.66) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL27594027 | 0.64 | MMP2 (0.44) | SMN1; SMN2ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL22862348 | 0.64 | — | — | |
| SCHEMBL6361424 | 0.63 | KCNQ3 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL30568974 | 0.63 | KCNQ3 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL2436172 | 0.62 | KCNQ3 (0.67) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762883-B1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 2001-11-14 | — | — | EP | disclosed |
| US-6083938-A | TREATING BONE DISEASES SELECTED FROM THE GROUP CONSISTING OF OSTEOLYTIC BONE DISEASES DUE TO MALIGNANCY, PAGET'S DISEASE AND PRIMARY AND SECONDARY OSTEOPOROSIS | LEIRAS OY (FI) | 2000-07-04 | — | — | US | disclosed |
| US-5866556-A | BONE DISORDERS | LEIRAS OY (FI) | 1999-02-02 | — | — | US | disclosed |