Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.49 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7782104 | 0.89 | PARP1 (0.56) | PARP1TNKS2TNKSWNT3APARP2 | |
| SCHEMBL7417121 | 0.75 | SMN1; SMN2 (0.46) | PARP1TNKS2TNKSWNT3APARP2 | |
| SCHEMBL19153490 | 0.74 | PARP1 (0.39) | PARP1TNKS2TNKSWNT3APARP2 | |
| SCHEMBL10150407 | 0.71 | PARP1 (0.59) | PARP1PARP15PARP3CYP1A2HIF1A | |
| SCHEMBL3122203 | 0.71 | PARP1 (0.59) | PARP1TNKS2TNKSWNT3APARP15 | |
| SCHEMBL9377703 | 0.69 | PARP1 (0.38) | PARP1TNKS2PARP15PARP3CYP1A2 | |
| SCHEMBL9879495 | 0.68 | ALDH1A1 (0.41) | PARP1TNKS2TNKSWNT3APARP2 | |
| SCHEMBL12102097 | 0.67 | PARP1 (0.42) | PARP1PARP15PARP3CYP1A2HIF1A | |
| SCHEMBL18711836 | 0.66 | PARP1 (0.62) | PARP1PARP15PARP3CYP1A2HIF1A | |
| SCHEMBL421328 | 0.66 | PARP1 (1.00) | PARP1TNKS2TNKSWNT3APARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142881-A1 | POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES | MEIJI SEIKA KAISHA LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |