Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7840180 | 0.81 | GABRD (0.53) | LMNA | |
| SCHEMBL5558534 | 0.81 | AKR1C1 (0.47) | LMNATSHRALDH1A1CYP2D6DAO | |
| SCHEMBL27963066 | 0.79 | SIGMAR1 (0.46) | SIGMAR1OPRM1LMNATSHRALDH1A1 | |
| SCHEMBL11761384 | 0.79 | OPRM1 (0.48) | SIGMAR1OPRM1LMNATSHRALDH1A1 | |
| SCHEMBL20228048 | 0.78 | SIGMAR1 (0.44) | SIGMAR1OPRM1LMNATSHRALDH1A1 | |
| SCHEMBL18321798 | 0.78 | SIGMAR1 (0.44) | SIGMAR1OPRM1LMNATSHRALDH1A1 | |
| SCHEMBL7312326 | 0.76 | OPRM1 (0.56) | SIGMAR1OPRM1HDAC1 | |
| SCHEMBL825722 | 0.75 | KDM4E (0.38) | OPRM1TSHRCYP2D6CYP1A2 | |
| SCHEMBL23467203 | 0.74 | SLC6A2 (0.47) | SIGMAR1OPRM1LMNACYP2D6SLC6A2 | |
| SCHEMBL14637529 | 0.74 | OPRM1 (0.43) | SIGMAR1OPRM1LMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140838-A1 | 1, 4-PIPERAZINE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035878-A1 | 1,4-PIPERAZINE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |