Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787608 | 0.90 | MAPKAPK2 (0.40) | MAPKAPK2STK10SLKMEN1POLB | |
| SCHEMBL7780332 | 0.86 | MEN1 (0.48) | MAPKAPK2MEN1POLBKMT2ABRAF | |
| SCHEMBL7780556 | 0.85 | ALDH1A1 (0.44) | MAPKAPK2MEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL7780336 | 0.84 | MAPKAPK2 (0.41) | MAPKAPK2MEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL7780311 | 0.82 | MEN1 (0.39) | MAPKAPK2MEN1POLBKMT2AMAPK14 | |
| SCHEMBL7787611 | 0.81 | MAPKAPK2 (0.46) | MAPKAPK2MEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL7787471 | 0.80 | BCL9 (0.36) | MAPKAPK2MEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL7780375 | 0.80 | KMT2A (0.42) | MAPKAPK2MEN1POLBKMT2AMAPK14 | |
| SCHEMBL7780593 | 0.80 | MAPKAPK2 (0.46) | MAPKAPK2MAPK14MTORKDM4ELMNA | |
| SCHEMBL7785265 | 0.79 | MAPKAPK2 (0.41) | MAPKAPK2MEN1POLBKMT2AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |