Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784998 | 0.90 | MAPKAPK2 (0.41) | MAPKAPK2STK10SLKPOLBMEN1 | |
| SCHEMBL7780411 | 0.87 | MEN1 (0.47) | MAPKAPK2POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7780560 | 0.86 | ALDH1A1 (0.44) | MAPKAPK2POLBMEN1KMT2ATP53 | |
| SCHEMBL7787655 | 0.86 | ALDH1A1 (0.44) | MAPKAPK2POLBMEN1KMT2ATP53 | |
| SCHEMBL7787545 | 0.81 | MAPKAPK2 (0.42) | MAPKAPK2MAPK14MTOR | |
| SCHEMBL7785589 | 0.81 | MAPKAPK2 (0.45) | MAPKAPK2MAPK14MTOR | |
| SCHEMBL7780407 | 0.81 | KRAS (0.41) | SMN1; SMN2SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL7787623 | 0.80 | CA1 (0.37) | MAPKAPK2POLBMEN1KMT2ACSF1R | |
| SCHEMBL7780621 | 0.80 | MAPKAPK2 (0.38) | MAPKAPK2POLBMEN1KMT2AMAPK14 | |
| SCHEMBL7780389 | 0.80 | KMT2A (0.41) | MAPKAPK2POLBMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |