Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785272 | 0.89 | KMT2A (0.41) | ALDH1A1TDP1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7785111 | 0.80 | CASR (0.45) | ALDH1A1TDP1KMT2AMEN1MAPT | |
| SCHEMBL7780324 | 0.80 | CRHBP (0.47) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL27530332 | 0.80 | NPC1 (0.54) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL27530335 | 0.80 | NPC1 (0.54) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL27530409 | 0.78 | MAPK1 (0.47) | ALDH1A1TDP1KMT2AMEN1MAPT | |
| SCHEMBL7785483 | 0.78 | MAPK1 (0.47) | ALDH1A1TDP1KMT2AMEN1MAPT | |
| SCHEMBL7785657 | 0.78 | SMN1; SMN2 (0.37) | ALDH1A1TDP1KMT2AMEN1MAPT | |
| SCHEMBL7785030 | 0.77 | MAPT (0.56) | ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7784992 | 0.75 | MAPT (0.46) | ALDH1A1TDP1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |