Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7575127 | 0.89 | SLC6A4 (0.39) | SLC6A4MAPTKDM4EDGAT1NPC1 | |
| SCHEMBL6819500 | 0.79 | DGAT1 (0.47) | SLC6A4MAPTKDM4EDGAT1NPC1 | |
| SCHEMBL6819503 | 0.79 | DGAT1 (0.47) | SLC6A4MAPTKDM4EDGAT1NPC1 | |
| SCHEMBL7872121 | 0.77 | CES2 (0.42) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6811082 | 0.77 | MAPT (0.45) | MAPTNPC1GAARAB9AKMT2A | |
| SCHEMBL6811077 | 0.77 | MAPT (0.45) | MAPTNPC1GAARAB9AKMT2A | |
| SCHEMBL6814924 | 0.74 | CES2 (0.47) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL6814922 | 0.74 | CES2 (0.47) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL7862677 | 0.70 | SLC6A4 (0.36) | SLC6A4DGAT1NPC1ALDH1A1LMNA | |
| SCHEMBL7862674 | 0.70 | RAB9A (0.46) | SLC6A4MAPTDGAT1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144397-A3 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | Wyeth (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1144397-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000034258-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |