Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 13/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502379 | 0.83 | EPAS1 (0.47) | EPAS1CA1CA2 | |
| SCHEMBL20193401 | 0.83 | EPAS1 (0.37) | EPAS1CA1CA2DRD2DRD1 | |
| SCHEMBL29134970 | 0.81 | EPAS1 (0.43) | EPAS1CA1CA2 | |
| SCHEMBL18183948 | 0.81 | EPAS1 (0.36) | EPAS1CA1CA2DRD2DRD1 | |
| SCHEMBL5787332 | 0.80 | ALDH1A1 (0.43) | EPAS1PTGS2PTGS1CA1CA2 | |
| SCHEMBL2860586 | 0.78 | CA1 (0.42) | EPAS1CA1CA2DRD2DRD1 | |
| SCHEMBL31265243 | 0.78 | CA1 (0.42) | EPAS1CA1CA2DRD2DRD1 | |
| SCHEMBL12275709 | 0.78 | CA2 (0.37) | EPAS1CA1CA2DRD2DRD1 | |
| SCHEMBL12294158 | 0.78 | CA2 (0.37) | EPAS1CA1CA2DRD2DRD1 | |
| SCHEMBL2469383 | 0.76 | NOTUM (0.57) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854849-B1 | ETHYNYL SUBSTITUTED AROMATIC COMPOUNDS, SYNTHESIS, POLYMERS AND USES THEREOF | DOW CHEMICAL CO (US) | 2001-10-31 | — | — | EP | disclosed |
| US-6252001-B1 | ACETYLENIC POLYMER | THE DOW CHEMICAL COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6121495-A | Ethynyl substituted aromatic compounds, synthesis, polymers and uses thereof | THE DOW CHEMICAL COMPANY (US) | 2000-09-19 | — | — | US | disclosed |