Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787663 | 0.87 | TDP1 (0.40) | TDP1MEN1KMT2APOLBCASR | |
| SCHEMBL7803612 | 0.86 | TDP1 (0.45) | TDP1MEN1KMT2APOLBCASR | |
| SCHEMBL7784888 | 0.85 | MEN1 (0.39) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL7785270 | 0.84 | KMT2A (0.38) | MEN1KMT2APOLBALDH1A1HTT | |
| SCHEMBL7787653 | 0.84 | KMT2A (0.38) | MEN1KMT2APOLBALDH1A1HTT | |
| SCHEMBL7780305 | 0.84 | KMT2A (0.38) | MEN1KMT2APOLBALDH1A1HTT | |
| Trifluoroacetic Acid SCHEMBL7787660 | 0.83 | TDP1 (0.43) | TDP1MEN1KMT2AALDH1A1KLKB1 | |
| SCHEMBL7780429 | 0.82 | TDP1 (0.42) | TDP1MEN1KMT2APOLBCASR | |
| SCHEMBL7785532 | 0.79 | KMT2A (0.38) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL7787592 | 0.79 | KMT2A (0.38) | MEN1KMT2APOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |