Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780337 | 0.91 | ALDH1A1 (0.40) | TDP1ALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7780313 | 0.90 | TDP1 (0.41) | TDP1ALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7780556 | 0.83 | ALDH1A1 (0.44) | ALDH1A1LMNAGAAMEN1POLB | |
| SCHEMBL7789113 | 0.83 | KMT2A (0.44) | TDP1ALDH1A1GAAMEN1POLB | |
| SCHEMBL7785567 | 0.82 | TDP1 (0.42) | TDP1ALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7784885 | 0.82 | KMT2A (0.43) | TDP1ALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7785061 | 0.81 | KMT2A (0.44) | TDP1ALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7784907 | 0.81 | SIGMAR1 (0.44) | TDP1ALDH1A1LMNAMEN1POLB | |
| SCHEMBL7787489 | 0.81 | ALDH1A1 (0.39) | TDP1ALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7784878 | 0.80 | ALDH1A1 (0.68) | ALDH1A1LMNAGAAMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |