Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 8/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785252 | 0.88 | MAPKAPK2 (0.40) | MAPKAPK2CXCR2MAPK14 | |
| Hydrochloric Acid SCHEMBL7785103 | 0.87 | MAPKAPK2 (0.40) | MAPKAPK2CXCR2MAPK14 | |
| SCHEMBL7802226 | 0.85 | MAPKAPK2 (0.34) | MAPKAPK2MAPK14HSD17B1HSD17B2 | |
| Trifluoroacetic Acid SCHEMBL7802224 | 0.85 | CXCR2 (0.38) | CXCR2CXCR1 | |
| SCHEMBL7780735 | 0.85 | MAPKAPK2 (0.38) | MAPKAPK2CXCR2MAPK14 | |
| SCHEMBL7789434 | 0.85 | MAPKAPK2 (0.38) | MAPKAPK2CXCR2MAPK14 | |
| Trifluoroacetic Acid SCHEMBL7780339 | 0.84 | MAPKAPK2 (0.42) | MAPKAPK2CXCR2MAPK14CXCR1DPP4 | |
| Trifluoroacetic Acid SCHEMBL7787645 | 0.84 | MAPKAPK2 (0.36) | MAPKAPK2CXCR2MAPK14CXCR1 | |
| Hydrochloric Acid SCHEMBL7803654 | 0.84 | MAPKAPK2 (0.37) | MAPKAPK2CXCR2MAPK14 | |
| SCHEMBL7801400 | 0.84 | S1PR3 (0.38) | MAPKAPK2CXCR2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |