Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CUL4A | Q13619 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787933 | 0.79 | HCAR2 (0.35) | — | |
| SCHEMBL7780833 | 0.78 | MEN1 (0.31) | TSHR | |
| SCHEMBL8983616 | 0.77 | — | — | |
| SCHEMBL1465185 | 0.70 | KDM4E (0.43) | HSD17B10KDM4EMAPTALDH1A1HTT | |
| SCHEMBL7996741 | 0.70 | KDR (0.49) | HSD17B10HPGDCYP3A4ALOX15CYP2C19 | |
| SCHEMBL30420965 | 0.67 | L3MBTL1 (0.42) | HSD17B10KDM4EHPGDCYP3A4ALOX15 | |
| SCHEMBL4634558 | 0.67 | KDM4E (0.51) | HSD17B10KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL19127706 | 0.67 | CYP3A4 (0.47) | HSD17B10KDM4EHPGDCYP3A4ALOX15 | |
| SCHEMBL9408875 | 0.66 | MEN1 (0.41) | HSD17B10KDM4ECYP3A4MAPTALDH1A1 | |
| SCHEMBL9319778 | 0.66 | KDM4E (0.41) | HSD17B10KDM4EHPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001085715-A2 | AZA- AND POLYAZANTHRANYL AMIDES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2001-11-15 | — | — | WO | disclosed |
| EP-0964855-B1 | PROCESS FOR PREPARING SUBSTITUTED PYRIMIDINE DERIVATIVES | LONZA AG (CH) | 2001-10-17 | — | — | EP | disclosed |
| EP-0964855-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRIMIDINE DERIVATIVES | LONZA A.G. (CH) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998030549-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRIMIDINE DERIVATIVES | LONZA AG (CH) | 1998-07-16 | — | — | WO | disclosed |