SCHEMBL77860

SCHEMBL77860

CN(C(=O)C1CC1)c1nc(C(C)(C)C)cs1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UCHL1 P09936 7/20 0.60
ATAD2 Q6PL18 1/20 0.48
MAPT P10636 1/20 0.43
ALDH1A1 P00352 2/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.37
USP30 Q70CQ3 6/20 0.36
CPB1 P15086 1/20 0.36
CNR2 P34972 1/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
KDM4E B2RXH2 1/20 0.36
LMNA P02545 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HTR1A P08908 1/20 0.35
HTR2A P28223 1/20 0.35
HTR7 P34969 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
KMT2A Q03164 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10931661 0.78 UCHL1 (0.49) UCHL1ATAD2MAPTALDH1A1NPC1
SCHEMBL91727 0.77 MAPT (0.43) UCHL1MAPTALDH1A1USP30CPB1
SCHEMBL20359230 0.76 UCHL1 (1.00) UCHL1USP30
SCHEMBL20359231 0.76 UCHL1 (1.00) UCHL1USP30
SCHEMBL13658019 0.71 ALDH1A1 (0.53) UCHL1ATAD2MAPTALDH1A1NPC1
SCHEMBL15689336 0.71 NPC1 (0.70) UCHL1MAPTALDH1A1USP30CPB1
SCHEMBL20789390 0.70 GRM1 (0.44) UCHL1MAPTALDH1A1NPC1RAB9A
SCHEMBL77715 0.70 ATAD2 (0.89) ATAD2MAPTALDH1A1CNR2NPC1
SCHEMBL17107203 0.69 UCHL1 (0.63) UCHL1MAPTALDH1A1USP30CPB1
SCHEMBL17107125 0.68 UCHL1 (0.62) UCHL1MAPTALDH1A1USP30CPB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129415-B2 Fungicide hydroximoyl-tetrazole derivatives BAYER CROPSCIENCE AG (DE) 2012-03-06 US disclosed
US-20090192196-A1 Fungicide hydroximoyl-tetrazole derivatives BAYER CROPSCIENCE AG (DE) 2009-07-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090192196-A1 Fungicide hydroximoyl-tetrazole derivatives HAAO, HAO1, CYP51A1 UCHL1 1230/4885ATAD2 2381/4885MAPT 2769/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.