Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.54 |
| ▸ | DRD3 | P35462 | 11/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | HTR1D | P28221 | 5/20 | 0.49 |
| ▸ | HTR1B | P28222 | 3/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22702276 | 0.74 | DRD2 (0.57) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL22702312 | 0.74 | DRD2 (0.57) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7424159 | 0.73 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7424155 | 0.73 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7336392 | 0.72 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7336396 | 0.72 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL5811739 | 0.72 | DRD2 (0.42) | DRD2MTNR1AMTNR1B | |
| SCHEMBL7434490 | 0.72 | HTR1D (0.81) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL14422957 | 0.71 | DRD2 (0.72) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL14847040 | 0.70 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717620-B1 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5382596-A | Useful for alleviating Parkinsonism, glaucoma, hyperprolactinemia and for inducing weight loss in mammals | WHITBY RESEARCH, INC. (US) | 1995-01-17 | — | — | US | disclosed |