Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | HAT1 | O14929 | 3/20 | 0.36 |
| ▸ | EP300 | Q09472 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785210 | 0.94 | SIGMAR1 (0.43) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7787489 | 0.91 | ALDH1A1 (0.39) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7789113 | 0.89 | KMT2A (0.44) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7785298 | 0.89 | KMT2A (0.44) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7787621 | 0.87 | KMT2A (0.43) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7780340 | 0.85 | KMT2A (0.42) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7785275 | 0.85 | ADRB3 (0.46) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7784907 | 0.84 | SIGMAR1 (0.44) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7785268 | 0.83 | NPC1 (0.45) | KMT2AMEN1POLBTDP1NPC1 | |
| SCHEMBL7780313 | 0.83 | TDP1 (0.41) | KMT2AMEN1POLBTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |