Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.39 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780405 | 0.92 | LMNA (0.48) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7780373 | 0.92 | LMNA (0.48) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL27556854 | 0.89 | MAPK1 (0.48) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7785304 | 0.89 | MAPK1 (0.48) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7785688 | 0.87 | CRHBP (0.44) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL7780359 | 0.86 | MAPT (0.41) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7780564 | 0.86 | MAPK1 (0.46) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7785152 | 0.86 | MAPK1 (0.46) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7784992 | 0.86 | MAPT (0.46) | ABCG2MAPTLMNAALDH1A1NPC1 | |
| SCHEMBL7780773 | 0.85 | SMN1; SMN2 (0.43) | ABCG2MAPTLMNAALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |