Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785688 | 0.85 | CRHBP (0.44) | SMN1; SMN2KMT2AMEN1PGRAR | |
| SCHEMBL7787619 | 0.85 | PFKFB3 (0.42) | RAB9AKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL7780359 | 0.84 | MAPT (0.41) | SMN1; SMN2RAB9AKMT2AMEN1MAPT | |
| SCHEMBL7780405 | 0.84 | LMNA (0.48) | SMN1; SMN2RAB9AKMT2AMEN1MAPT | |
| SCHEMBL7780373 | 0.84 | LMNA (0.48) | SMN1; SMN2RAB9AKMT2AMEN1MAPT | |
| SCHEMBL7780407 | 0.81 | KRAS (0.41) | SMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL7785661 | 0.80 | MAPK1 (0.39) | SMN1; SMN2RAB9AKMT2AMEN1CYP3A4 | |
| SCHEMBL7785302 | 0.80 | HTT (0.46) | SMN1; SMN2KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7789050 | 0.79 | ALDH1A1 (0.40) | SMN1; SMN2KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL7780324 | 0.78 | CRHBP (0.47) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |