Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824914 | 0.91 | ALDH1A1 (0.63) | ALDH1A1LMNAMAPTMAPK1RAF1 | |
| SCHEMBL10585792 | 0.87 | ALDH1A1 (0.67) | ALDH1A1LMNAMAPTMAPK1RAF1 | |
| SCHEMBL4818648 | 0.87 | CYP3A4 (0.69) | TTRALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL7785541 | 0.86 | TTR (0.59) | TTRALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL7365333 | 0.85 | TTR (0.75) | TTRALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL4818681 | 0.83 | ALDH1A1 (0.59) | ALDH1A1LMNAMAPTMAPK1RAF1 | |
| SCHEMBL4818707 | 0.83 | TUBB4A (0.62) | ALDH1A1MAPTCYP3A4TSHRTDP1 | |
| SCHEMBL2156946 | 0.82 | ALDH1A1 (0.63) | TTRALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL232059 | 0.81 | ALDH1A1 (0.61) | ALDH1A1CYP3A4TSHRTDP1SMN1; SMN2 | |
| SCHEMBL4337680 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNAMAPTCYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |