Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3885369 | 0.80 | SIRT2 (0.55) | SIRT2ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL7749893 | 0.77 | DRD4 (0.55) | SIRT2ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL29191130 | 0.76 | SIRT2 (0.51) | SIRT2ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL27975623 | 0.76 | SIRT2 (0.48) | SIRT2ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL28016150 | 0.76 | ALDH1A1 (0.50) | SIRT2ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL1951649 | 0.76 | LMNA (0.56) | SIRT2ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL3355193 | 0.76 | MAPT (0.49) | SIRT2ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL30168551 | 0.76 | MAPT (0.49) | SIRT2ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL12933435 | 0.76 | SIRT2 (0.48) | SIRT2ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL27334728 | 0.75 | LMNA (0.55) | SIRT2ALDH1A1LMNAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161418-A1 | 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS | MEDICAL RESEARCH COUNCIL (GB) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055133-A1 | 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS | MEDICAL RESEARCH COUNCIL (GB) | 2000-09-21 | — | — | WO | disclosed |