Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ACP3 | P15309 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11442189 | 0.85 | APP (0.55) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL11432821 | 0.84 | TSHR (0.61) | MAPTALDH1A1TDP1SMN1; SMN2LMNA | |
| SCHEMBL7785663 | 0.83 | NFE2L2 (0.55) | NFE2L2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL7801278 | 0.83 | NFE2L2 (0.55) | NFE2L2MAPTALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7787525 | 0.82 | NFE2L2 (0.53) | NFE2L2MAPTALDH1A1NPC1RAB9A | |
| Trimethylammonium SCHEMBL28709705 | 0.81 | NFE2L2 (0.52) | NFE2L2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL8402461 | 0.78 | NFE2L2 (0.47) | NFE2L2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL7788967 | 0.78 | MAPK1 (0.51) | NFE2L2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL5243706 | 0.77 | TSHR (0.52) | NFE2L2MAPTALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL15325817 | 0.77 | ALDH1A1 (0.58) | NFE2L2MAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |