Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL132013 | 0.84 | KCNH2 (0.49) | KCNH2HRH3LTA4HLSSSMN1; SMN2 | |
| SCHEMBL8365860 | 0.81 | KCNH2 (0.43) | KCNH2HRH3LTA4HLSSACKR3 | |
| SCHEMBL668013 | 0.81 | NISCH (0.46) | KCNH2HRH3LTA4HSMN1; SMN2ALDH1A1 | |
| SCHEMBL27466866 | 0.81 | HRH3 (0.46) | KCNH2HRH3LTA4HSMN1; SMN2ALDH1A1 | |
| SCHEMBL2045962 | 0.79 | NISCH (0.49) | KCNH2HRH3LTA4HSMN1; SMN2 | |
| SCHEMBL8143013 | 0.79 | KCNH2 (0.42) | KCNH2HRH3LTA4HLSSACKR3 | |
| SCHEMBL3607804 | 0.79 | ALDH1A1 (0.47) | KCNH2HRH3LTA4HLSSSMN1; SMN2 | |
| SCHEMBL20410837 | 0.76 | KCNH2 (0.44) | KCNH2HRH3LTA4HLSSSMN1; SMN2 | |
| SCHEMBL10520360 | 0.76 | KCNH2 (0.48) | KCNH2HRH3LTA4HLSSSMN1; SMN2 | |
| SCHEMBL9475161 | 0.76 | KCNH2 (0.44) | KCNH2HRH3LTA4HLSSSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251898-B1 | Medical use of fluorenone derivatives for treating and preventing brain and spinal injury | QUESTCOR PHARMACEUTICALS, INC. | 2001-06-26 | — | — | US | disclosed |
| WO-2001014334-A1 | FLUORENONE COMPOUNDS WITH MODIFIED 7-POSITION SUBSTITUENTS FOR TREATING AND PREVENTING BRAIN AND SPINAL INJURY | QUESTCOR PHARMACEUTICALS, INC. (US) | 2001-03-01 | — | — | WO | disclosed |
| EP-0397276-B1 | Functionalized elastomeric polymers | SHELL INT RESEARCH (NL) | 1995-07-26 | — | — | EP | disclosed |
| US-5015695-A | Producing heat-curable elastomer from elastomer with two or more pendant carboxylates and propargyl, styrylmethyl or 4-/2-oxazolinyl/benzyl halide in polar diluent | SHELL OIL COMPANY (US) | 1991-05-14 | — | — | US | disclosed |
| US-4978719-A | HAVING PENDANT CARBOXYLIC ACID ESTER GROUP WITH REACTIVE UNSATURATION; SUCH AS PROPARGYL, STYRYLMETHYL OR 4-/2-OXAZO-LINYL/BENZYL; SELF-CURING | SHELL OIL COMPANY (US) | 1990-12-18 | — | — | US | disclosed |
| EP-0397276-A2 | Functionalized elastomeric polymers | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-11-14 | — | — | EP | disclosed |