Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.35 |
| ▸ | TDO2 | P48775 | 3/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | C1S | P09871 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8696092 | 0.87 | IDO1 (0.37) | IDO1TDO2TAAR1SIGMAR1ALDH1A1 | |
| SCHEMBL10503151 | 0.75 | MIF (0.35) | ALDH1A1MAPK1 | |
| SCHEMBL10502034 | 0.70 | ALDH1A1 (0.38) | ALDH1A1MAPK1 | |
| SCHEMBL7793217 | 0.69 | HTR3E (0.44) | IDO1TAAR1SIGMAR1MAPK1TP53 | |
| SCHEMBL1047547 | 0.68 | TAAR1 (0.57) | IDO1TAAR1SIGMAR1 | |
| SCHEMBL30102043 | 0.67 | ALDH1A1 (0.46) | IDO1TDO2TAAR1ALDH1A1MAPK1 | |
| SCHEMBL7172274 | 0.67 | ALDH1A1 (0.46) | IDO1TDO2TAAR1ALDH1A1MAPK1 | |
| SCHEMBL7172271 | 0.67 | ALDH1A1 (0.46) | IDO1TDO2TAAR1ALDH1A1MAPK1 | |
| SCHEMBL1971584 | 0.67 | ALDH1A1 (0.46) | IDO1TDO2TAAR1SIGMAR1ALDH1A1 | |
| SCHEMBL6154600 | 0.67 | MAOB (0.44) | IDO1TAAR1SIGMAR1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |