Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PMM2 | O15305 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647727 | 0.80 | KMT2A (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7794049 | 0.79 | HTR3A (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7648045 | 0.75 | KMT2A (0.44) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7790019 | 0.75 | HTR3E (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7790485 | 0.69 | ITGB3 (0.41) | MAPK1ITGB3ITGAVKMT2AHSD17B10 | |
| SCHEMBL7789998 | 0.69 | IDO1 (0.35) | MAPK1TAAR1TP53IDO1SIGMAR1 | |
| SCHEMBL10503151 | 0.68 | MIF (0.35) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9026682 | 0.67 | IGF1R (0.67) | KMT2ATAAR1MAPTIGF1RALOX15 | |
| SCHEMBL7648246 | 0.65 | MAPK1 (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7008253 | 0.65 | IGF1R (0.65) | KMT2ATAAR1MAPTIGF1RALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |