Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7790476 | 0.80 | LMNA (0.46) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7790011 | 0.79 | NPC1 (0.56) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL28975690 | 0.79 | MEN1 (0.64) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL2230140 | 0.79 | NPC1 (0.79) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL124395 | 0.79 | NPC1 (0.79) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27945424 | 0.77 | NPC1 (0.76) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| Bicarbonate SCHEMBL11025569 | 0.77 | NPC1 (0.76) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL23573585 | 0.76 | RAB9A (0.60) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL23573586 | 0.76 | RAB9A (0.60) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL9270161 | 0.76 | ALDH1A1 (0.61) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |